Check out our steerable detectors if you lost your (biological) patterns in noisy backgrounds 🙂 https://ieeexplore.ieee.org/document/9406375
A single-shot template learning will allow finding all occurrences no matter their orientation are and with high recall and specificity !
And it is obviously all packaged in an open-source ImageJ plugin!
http://bigwww.epfl.ch/algorithms/steer_n_detect
Plus open source code on GitHub:
https://github.com/Biomedical-Imaging-Group/Steer-n-Detect
Joint work with Julien Fageot, Virginie Uhlmann, Zsuzsanna Püspöki, Benjamin Beck and Michael Unser.