Our paper “Sharpening Local Interpretable Model-agnostic Explanations for Histopathology: Improved Understandability and Reliability” by Mara Graziani, Iam Palatnik De Sousa et. al will be presented at MICCAI 2021, Sept. 27 to Oct 1st, Strasbourg, France.
In this work, we improve the application of LIME to histopathology images by leveraging nuclei annotations. The obtained visualizations reveal the sharp, neat and high attention of the deep classifier to the neoplastic nuclei in the dataset, an observation in line with clinical decision making.
Compared to standard LIME, our explanations show improved understandability for domain-experts, report higher stability and pass the sanity checks of consistency to data or initialization changes and sensitivity to network parameters.