The management of brain metastases (BM) remains challenging due to their heterogeneous response to stereotactic radiosurgery (SRS) and the difficulty of distinguishing tumor recurrence from radiation necrosis on follow-up imaging. Conventional MRI often lacks specificity, while the increasing volume and complexity of multimodal imaging data make manual analysis time-consuming and variable. Artificial intelligence (AI) and radiomics offer promising tools to extract quantitative imaging features, automate tumor segmentation, and support prediction of treatment response and outcomes. This collaborative project between CHUV and HES-SO, funded by the Swiss National Science Foundation (SNSF), aims to leverage a large longitudinal imaging dataset to develop AI-based methods for BM data curation, automated segmentation, and predictive modeling, ultimately supporting more precise treatment planning and follow-up for patients with brain metastases.
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Andrearczyk, V., Schiappacasse, L., Abler, D., Wodzinski, M., Hottinger,
A., Raccaud, M., Bourhis, J., Prior, J.O., Dunet, V., Depeurnge, A.: Auto-
matic detection and multi-component segmentation of brain metastases in
longitudinal mri. Scientific reports 14(1), 31603 (2024)
Andrearczyk, V., Schiappacasse, L., Raccaud, M., Bourhis, J., Prior, J.O.,
Cuendet, M.A., Hottinger, A.F., Dunet, V., Depeursinge, A.: The value of
ai for assessing longitudinal brain metastases treatment response. Neuro-
Oncology Advances 7(1), vdae216 (01 2025). https://doi.org/10.1093/noajnl/vdae216
Kuhn, L.A., Abler, D., Richiardi, J., Hottinger, A.F., Schiappacasse, L., Dunet, V., Depeursinge, A., Andrearczyk, V.: AI-based response assessment and prediction in longitudinal imaging for brain metastases treated with stereotactic radiosurgery, ArXiv. https://arxiv.org/abs/2509.06396
Sychold E, de Cournuaud C, Danthez N, Kinj R, Vallet V, Gondre M, Hottinger A, Andrearczyk V, Dunet V, Depeursinge A, Schiappacasse L. RDTA-08 MULTI-SEQUENTIAL STEREOTACTIC RADIOSURGERY (SRS) FOR BRAIN METASTASES: 10-YEAR EXPERIENCE FROM THE CHUV (LAUSANNE, SWITZERLAND) BRAIN METASTASIS CLINIC. Neurooncol Adv. 2025 Aug 8;7(Suppl 2):ii26. doi: 10.1093/noajnl/vdaf123.096. PMCID: PMC12342458.
Andrearczyk, V., Kuhn, L.A., Abler, D., Richiardi, J., Hottinger, A.F., Schiappacasse, L., Dunet, V., Depeursinge, A.: AI for Longitudinal Brain Metastasis Management